Hyperthermia: Biology, Physics and Instrumentations
高溫腫瘤學
Instructor: Win-Li Lin*, Institute of Biomedical Engineering
Time: Friday 14:20-17:20
Classroom: College of Medicine # 504

一、課程簡介:
1.Historical review
2.Biological principles
　a.Molecular and cellular mechanism of hyperthrmia
　b.Thermotolerance
　c.Interaction of heat and radiation
　d.Interaction of heat and drug
　e.Thermal dosimetry
3.Pathophysiological mechanisms
a.Microvasculature and perfusion in normal tissues and tumors
b.Metabolic status and reaction to heat of normal and tumor tissue
c.Manipulation of physiological parameters during hyperthermia
4.Physical principles and instrumentations
a.Electromagnetic heating technology
b.Ultrasound heating technology
c.Interstitial and intracavitary heating technology
d.Thermometry and thermal control
e.Thermal models and power deposition models
f.Treatment planning and quality assurance
5.Clinical applications of hyperthermia
a.Clinical rationale for thermoradiotherapy
b.Clinical rationale for thermochemotherapy
c.Thermoradiotherapy for superficial tumors
d.Thermoradiotherapy for deep tumors
e.Whole-body hyperthermia
6.Future clinical research
a.Considerations for hyperthermia clinical trials design
b.Standardized thermoradiotherapy treatment documentation
c.Tabulation of parameters for hyperthermic data evaluation

二.參考書目:
1.Seegenschmiedt MH, Fessenden P, and Vernon CC, 1995, Thermradiotherapy and Thermochemotherapy Vol. 1 and 2, Springer.
2.Matsuda T, 1993, Cancer treatment by Hyperthermia, Radiation and Drugs, Taylor & Francis.

* Win-Li Lin: Received a Ph.D. from the University of Arizona, USA, in 1990. From 1990-1992, he was a researcher at the Industrial Technology Research Institute, developing ultrasound diagnostic equipment. In 1992, he joined the faculty of The Institute (Center) of Biomedical Engineering, National Taiwan University and became a full professor in 2001. He has been interested in biomedical engineering research, particularly in the areas: a) ultrasound hyperthermia, ultrasound thermal therapy/surgery, and the development of high-power ultrasound devices for cancer therapy or other medical uses; b) acoustic biosensor for molecular recognition; c) bioinformatics.